Publications 2000 - 2011

Kakuschke, A., Valenthine-Thon, E., Griesel, S., Fonfara, S., Siebert, U., & Prange, A. (2011): Are metal-induced hypersensitivities in harbor seals associated with liver function? Marine Pollution Bulletin, doi:10.1016/j.marpolbul.2011.05.034
Grebe, M., Pröfrock, D., Kakuschke, A., Broekaert, J., & Prange, A. (2011): Absolute quantitation of transferrin in blood samples of harbour seals using HPLC-ICP-MS. Metallomics 3(2), 176 - 185, doi:10.1039/c0mt00076k
Helmholz, H., Dong, Z., Ruhnau, C., & Liu, D. (2011): Investigation on fish gill cell toxicity and haemolytic activity of Nemopilema nomurai (Scyphozoa, Rhizostoma) from the northern Yellow Sea of China. Current Topics in Toxicology 7, 79-87
Helmholz, H. (2011): Natural Substances of Marine Origin with Toxic Properties. In: Quante, M. (et al. (eds): Persistent Pollution - Past, Present and Future. Chapter 17, 319-335
Lassen, S., Helmholz, H., Ruhnau, C., & Prange, A. (2011): A novel proteinaceous cytotoxin from the northern Scyphozoa Cyanea capillata (L.) with structural homology to cubozoan hemolysins. Toxicon 57, 721 - 729, doi:10.1016/j.toxicon.2011.02.004
Kakuschke, A., Valentine-Thone, E., Griesel, S., Gandrass, J., Perez Luzardo, O., Dominguez Boada, L., Zumbado Pena, M., Almeida Gonsalez, M., Grebe, M., Proefrock, D., Erbslöh, H.-B., Kramer, K., Fonfara, S., & Prange, A. (2010): First health and pollution study on harbor seals (Phoca vitulina) living in the German Elbe estuary. Mar Pol Bul 60, 2079-2086, doi:10.1016/j.marpolbul.2010.07.011
Pröfrock, D. (2010): Hyphenation of capillary-LC with ICP-MS and parallel on-line micro fraction collection for MALDI-TOF-TOF analysis - complementary tools for protein phosphorylation analysis. JAAS 25, 334-344, doi:10.1039/B921145D
Prange, A., & Pröfrock, D. (2010): Sample introduction in ICP-MS: Capillary electrophoresis. In: Beauchemin, D., & Mattews, D.E. (eds) The Encyclopedia of Mass Spectrometry 5, 46-58
Grebe, M., Pröfrock, D., Kakuschke, A., Broekaert, J., & Prange, A. (2010): Metallomics approach for the identification of the iron transport protein transferrin in blood from harbour seals (Phoca vitulina). Metallomics 2(10), 683-693, doi:10.1039/c0mt00009d
Pröfrock, D. (2010): Progress and possibilities of using miniaturized separation techniques and element mass spectrometry for quantitative bio-analysis. Analytical and Bioanalytical Chemistry 389, 2383-2401
Helmholz, H. (2010): Selelective toxin-lipid membrane interactions of natural, haemolytic Scyphozoan toxin analyzed by surface plasmon resonance. Biochimica et Biophysica Acta - Biomembranes 1798, 1944-1952, doi:10.1016/j.bbamem.2010.06.014
Helmholz, H., Johnston, B., Ruhnau, C., & Prange, A. (2010): Gill cell toxicity of northern boreal scyphomedusae Cyanea capillata and Aurelia aurita measured by an in vitro cell assay. Hydrobiologia 645, 223-234
Lassen, S., Helmholz, H., Ruhnau, C., & Prange, A. (2010): Characterisation of neurotoxic polypeptides from Cyanea capillata medusae (Scyphozoa). Hydrobiologia 645, 213-221
Wiebring, A., Helmholz, H., Lassen, S., Prange, A., & Jarms, G. (2010): Separation and analysis of different types of nematocysts from Cyanea capillata (L.) medusae. Hydrobiologia 645, 203-212
Wiebring, A., Helmholz, H., Sötje, I., Lassen, S., Prange, A., & Tiemann, H. (2010): Development of a new micromanipulation method for the separation of different types of nematocysts utilizing laser catapulting. Journal of Marine Biotechnology 12, 308-317
Kakuschke, A., Erbslöh, H.-B., Griesel, S., & Prange, A. (2009): Acute phase haptoglobin in blood plasma samples of harbor seals (Phoca vitulina) of the Wadden Sea and of the island of Helgoland. Comparative Biochemistry and Physiology, Part B 155, 67-71, doi:10.1016/j.cbpb.2009.10.002
Kakuschke, A., Valentine-Thon, E., Fonfara, S., Kramer, K., & Prange, A. (2009): Effects of methyl-, phenyl-, ethylmercury and mercurychloride on immune cells of harbor seals (Phoca vitulina). Journal of Environmental Sciences 21, 1716-1721
Künstl, L., Griesel, S., Prange, A., & Gössler W (2009): Arsenic speciation in body fluids of harbor seals (Phoca vitulina) and harbor porpoises (Phocoena phocoena). Environmental Chemistry 6, 319-327, doi:10.1071/EN08079
Pröfrock, D., & Prange, A. (2009): Compensation of gradient related effects when using capillary liquid chromatography and inductively coupled plasma mass spectrometry for the absolute quantification of phosphylated peptides. Journal of Chromatography A 1216, 6706-6715, doi:10.1016/j.chroma.2009.08.002
Rosenfeld, H., Lassen, S., & Prange, A. (2009): Characterization of haptoglobin in blood plasma of harbour seals (Phoca vitulina). Journal of Proteome Research 8, 2923-2932, doi:10.1021/pr900035s
Fahrenholtz, S., Griesel, S., Pröfrock, D., & Kakuschke, A. (2009): Essential and non-essential elements in tissues of harbour porpoises (Phocoena phocoena) stranded on the coasts of the Northern and Baltic Seas between 2004-2006. Journal of Environmental Monitoring 11, 1107-1113, doi:10.1039/B821504A
Kakuschke, A., Griesel, S., Fonfara, S., Rosenberger, T., & Prange, A. (2009): Concentrations of essential and non-essential elements in blood of harbor seals (Phoca vitulina) pups of the German North Sea. Biological Trace Element Research 127, 28-36, doi:10.1007/s12011-008-8220-x
Hasselmeier, I., Fonfara, S., Driver, J., & Siebert, U. (2008): Differential hematotoly profiles of free-ranging, rehabilitated and captive harbour seals (Phoca vitulina) of the german North Sea. Aquatic Mammals 34, 149-156
Fonfara, S., Kakuschke, A., Rosenberger, T., Siebert, U., & Prange, A. (2008): Changes of cytokine and acute phase protein expression in blood samples of harbour seal pups during their first months of marine life. Marine Biology 155, 337-345
Kakuschke, A., Valentine-Thon, E., Griesel, S., Rosenberger, T., Mundry, R., Siebert, U., & Prange, A. (2008): Blood metal levels and metal-influenced immune functions of harbour seals in captivity. Mar Poll Bul 56, 764-769, doi:10.1016/j.marpolbul.2008.01.015
Prange, A., & Pröfrock, D. (2008): Chemical labels and natural element tags for the quantitative analysis of bio-molecules. J Anal At Spectrom 23, 432-459, doi:10.1039/B717916M
Kakuschke, A., Valentine-Thon, E., Fonfara, S., Griesel, S., Rosenberger, T., Siebert, U., & Prange, A. (2008): Metal-induced impairment of the cellular immunity of newborn harbour seals (Phoca vitulina). Archives of Environmental Contamination and Toxicology 55, 129-136, doi:10.1007/s00244-007-9092-3
Griesel, S., Kakuschke, A., Siebert, U., & Prange, A. (2008): Trace Element Concentrations in Blood of Harbor Seals (Phoca vitulina) from the Wadden Sea. Science of the Total Environment 392, 313-323, doi:10.1016/j.scitotenv.2007.10.062
Helmholz, H., Naatz, S., Lassen, S., & Prange, A. (2008): Isolation of a cytotoxic glycoprotein from the Scyphozoa Cyanea lamarckii by lectin-affinity chromatography and characterization of molecule interactions by surface plasmon resonance. Journal of Chromatography B 871, 60-66, doi:10.1016/j.jchromb.2008.06.040
Kakuschke, A., & Prange, A. (2007): The influence of metal pollution on the immune system - a potential stressor for marine mammals in the North Sea. International Journal of Comparative Psychology 20, 179-193
Wright, A.J., Aguilar Soto, N., Baldwin, A.L., Bateson, M., Beale, C.M., Clark, C., Deak, T., Edwards, E.F., Fernandez Rodriguez, A., Godinho, A., Hatch, L., Kakuschke, A., Lusseau, D., Martineau, D., Romero, L.M., Weilgart, L., Wintle, B., Notarbartolo di Sciara, G., & Martin, V. (2007): Do marine mammals experience stres related to anthropogenic noise? International Journal of Comparative Psychology 20, 274-31
Wright, A.J., Aguilar Soto, N., Baldwin, A.L., Bateson, M., Beale, C.M., Clark, C., Deak, T., Edwards, E.F., Fernandez Rodriguez, A., Godinho, A., Hatch, l., Kakuschke, A., Lusseau, D., Martineau, D., Romero, L.M., Weilgart, L., Wintle, B., Notarbartolo di Sciara, G., & Martin, V. (2007): Anthropogenic noise as a stressor in animals: a multidisciplinary perspective. International Journal of Comparative Psychology 20, 250-273
Lehnert, K., Fonfara, S., Wohlsein, P., & Siebert, U. (2007): Whale lice (Isocyamus delphinii ) on a harbour purpoise (Phocoena phocoena) from German waters. Veterinary Record 161, 526-528, doi:10.1136/vr.161.15.526
Fonfara, S., Siebert, U., & Prange, A. (2007): Cytokines as markers for infection in harbour porpoises (Phoconea phocoena). Marine Mammal Science 23, 931-942
Sonne, C., Fonfara, S., Dietz, R., Kirgegaard, M., Letcher, R., Shahmiri, S., Anderson, S., & Moller, P. (2007): Multiple cytokine and acute-phase protein gene transcription in West Greenland sledge dogs (Canis familaris) dietary exposed to organic environmental pollutants. Archives of Environmental Contamination and Toxicology 53, 110-118, doi:10.1007/s00244-006-0135-y
Fonfara, S., Siebert, U., Prange, A., & Colijn, F. (2007): The impact of stress on cytokine and haptoglobin mRNA expression in blood samples from harbour porpoises Phocoena phocoena. Journal of the marine Biological Association of the United Kingdom, 87, 305-311, doi:10.1017/S0025315407055567
Helmholz, H., Ruhnau, C., Schütt, C., & Prange, A. (2007): Comparative study on the cell toxicity and enzymatic activity of two northern scyphozoan species Cyanea capillata (L.) and Cyanea lamarckii (Péron & Léslueur). Toxicon 50, 53-64
Bettmer, J., Jakubowski, N., & Prange, A. (2006): Elemental Tagging in Inorganic Mass Spectrometric Bioanalysis. Analytical and Bioanalytical Chemistry, 386, 7-11, doi:10.1007/s00216-006-0557-4
Griesel, S., Mundry, R., Kakuschke, A., Fonfara, S., Siebert, U., & Prange, A. (2006): Mineral elements and essentiel trace elements in blood of seals of the North Sea measured by Total-reflection X-ray fluorescence analysis. Spectrochimica Acta, 61, 1158-1165, doi:10.1016/j.sab.2006.07.008
Kakuschke, A., Valentin-Thon, E., Fonfara, S., Griesel, S., Siebert, U., & Prange, A. (2006): Metal sensitivity of marine mammals: a case study of a grey seal (Halichoerus grypus). Marine Mammal Science, 22, 985-996, doi:10.1111/j.1748-7692.2006.00059.x
Montes-Bayon, M., Pröfrock, D., Sanz-Medel, A., & Prange, A. (2006): Direct comparison of Capillary Electrophoresis and Capillary Liquid Chromatography hyphenated to collision-cell ICP-MS for the investigation of Cd, Cu and Zn containing metalloproteins. Journal of Chromatograpgy A, 1114, 138-144
Knispel, T., Ruhnau, C., Lassen, S., Griesel, S., Prange, A., & Denkhaus, E. (2005): Nickel species analysis of human colonic tissue using liquid chromatography, gel electrophoresis and mass spectrometry. Analytical and Bioanalytical Chemistry, 383, 404-413
Hölemann, J.A., Schirmacher, M., & Prange, A. (2005): Seasonal variability of trace metals in the Lena River and the southeastern Laptev Sea: Impact of the spring freshet. Global and Planetary Change, 48, 112-125, doi:10.1016/j.gloplacha.2004.12.008
Prange, A., & Pröfrock, D. (2005): Application of CE-ICP-MS and CE-ESI-MS in Metalloproteomics - Challenges, Developments and Limitations. Analytical and Bioanalytical Chemistry, 383, 372-389, doi:10.1007/s00216-005-3420-0
Kakuschke, A., Valentin-Thon, E., Griesel, S., Fonfara, S., Siebert, U., & Prange, A. (2005): Immunological impact of metals in harbour seals (Phoca vitulina) of the North Sea. Environmental Science and Technology, 39, 7568-7575
Pepelnik, R., Karrasch, B., Niedergesäß, R., Erbslöh, B., Mehrens, M., Link, U., Herzog, M., & Prange, A. (2005): Influence on the flooding in 2002 on the plankton and the quality of water and sediment of the river Elbe over its longitudinal profile. Acta Hydrochimica and Hydrobiologica 33, 430-448, doi:10.1002/aheh.200400589
Pröfrock, D., Leonhard, P., Ruck, W., & Prange, A. (2005): Development and characterisation of a new interface for coupling capillary LC with collision-cell ICP-MS and its application for phosphorylation profiling of tryptic protein digests. Analytical and Bioanalytical Chemistry 381, 194-204, doi:10.1007/s00216-004-2930-5
Li, B., Bergmann, J., Lassen, S., Leonhard, P., & Prange, A. (2005): Distribution of elements binding to molecules with different molecular weights in aqueous extract of Antartic krill by size-exclusion chromatography coupled with inductively coupled plasma mass spectrometry. J. Chromatogr. B, 814, 83-91, doi:10.1016/j.jchromb.2004.10.008
Aulinger, A., Einax, J.W., & Prange, A. (2004): Setup and optimization of a PLS regression model for predicting element contents in river sediments. Chemometrics and Intelligent Laboratory Systems 72, 35-41, doi:10.1016/j.chemolab.2004.03.001
Bergmann, J., Lassen, S., & Prange, A. (2004): Determination of the absolute configuration of selenomethionine from antarctic krill by RP-HPLC/ICP-MS using chiral derivatization agents. Anal. Bioanal. Chem. 378, 1624-1629, doi:10.1007/s00216-003-2472-2
Proefrock, D., Leonhard, P., Wilbur, S., & Prange, A. (2004): Determination of heteroelement containing pesticides in environmental samples by GC hyphenated with collision cell ICP-MS as alternative sensitive element specific detector. JAAS, 19, 623-631
Bouyssiere, B., Leonhard, P., Proefrock, D., Baco, F., Wilbur, S., & Prange, A. (2004): Determination of sulfur containing compounds in petroleum products by capillary gas chromatography with collision cell ICP-MS. JAAS, 19, 700-702
Bouyssiere, B., Knispel, T., Ruhnau, C., Denkhaus, E., & Prange, A. (2004): Analysis of nickel species in cytosols of normal and malignant human colonic tissues using two dimensional liquid chromatography with ICP sector field MS detection. JAAS, 19, 196-200, doi:10.1039/B308607K
Proefrock, D., Prange, A., Schaumlöffel, D., & Ruck, W. (2003): Species analysis of metallothionein like proteins in liver tissues from Elbe Bream and Roe Deer by capillary electrophoresis - inductively coupled plasma mass spectrometry. Spectrochim. Acta 58B, 1403-1415
Proefrock, D., Leonhard, P., & Prange, A. (2003): Determination of sulphur in metallothionein like proteins using capillary electrophoresis hyphenated to inductively coupled plasma mass spectrometry with an octopole reaction cell. Anal. Bioanal. Chem. 377, 132-139, doi:10.1007/s00216-003-2041-8
Proefrock, D., Leonhard, P., & Prange, A. (2003): Determination of phosphorus in phosphorylated deoxribunucleotides using capillary electrophoresis and high performance liquid chromatography hyphenated to inductively coupled plasma mass spectrometry with an octopole reaction cell. JAAS, 18, 708-713
Wolf, C., Schaumlöffel, D., Richarz, A.-N., Prange, A., & Brätter, P. (2003): CZE-ICP-MS Separation of Metallothioneins in Human Brain: Comparability of Electropherograms Obtained from Different Sample Matrices. Analyst 128, 576-580
Szpunar, J., Lobinski, R., & Prange, A. (2003): Hyphenated techniques for elemental speciation in biological systems - Focal Point. Appl. Spectroscopy 57 (2003) 102A-112A, doi:10.1366/000370203321558128
Aulinger, A., Prange, A., Schmolke, S., Niedergesäss, R., & Einax, J. (2002): Characterization of the elemental charge of sediments and suspended particulate matter from the river Elbe using multielement analysis combined with chemometrical data evaluation. J. Environ. Monit., (2002) 4: 942-949
Polec, K., Schaumlöffel, D., Szpunar, J., Prange, A., & Lobinski, R. (2002): Analysis for metal complexes with metallothionein in rat liver by capillary zone electrophoresis using ICP quadrupole MS, ICP double-focussing sector-field isotope dilution MS and electrospray MS detection. J. Anal. At. Spectrom. (2002) 17, 908-912, doi:10.1039/B110579P
Prange, A., & Schaumlöffel, D. (2002): Hyphenated Techniques for the Characterization and Quantification of Metallothionein Isoforms. - Review-. Anal. Bioanal. Chem. (2002) 373:441-453, doi:10.1007/s00216-002-1350-7
Prange, A. (2002): Speziesanalyse mit gekoppelten Systemen: das Beispiel CE/ICP-MS. Nachrichten aus der Chemie (2002) 50:728-732, doi:10.1002/nadc.20020500618
Leonhard, P., Pepelnik, R., Prange, A., Yamada, N., & Yamada, T. (2002): Analysis of diluted Seawater at the ng/L-level using an ICP-MS with an Octopole Reaction/Collision Cell. J Anal At Spectrom (2002) 17:189-196, doi:10.1039/B110180N
Wang, Z., & Prange, A. (2002): Use of Surface-Modified Capillaries in the Separation and Characterization of Metallothionein Isoforms by Capillary Electrophoresis Inductively Coupled Plasma Mass Spectrometry. Anal Chem (2002) 74:626-631
Schaumlöffel, D., Prange, A., Marx, G., Heuman, K.G., & Brätter, P. (2002): Characterization and quantification of metallothionein isoforms by capillary electrophoresis-inductively coupled plasma-isotope-dilution mass spectrometry. Anal Bioanal Chem (2002) 372:155-163, doi:10.1007/s00216-001-1164-z
Prange, A., Schaumlöffel, D., Brätter, P., Richarz, A.-N., & Wolf, C. (2001): Species analysis of metallothionein isoforms in human brain cytosols by use of capillary electrophoresis hyphenated to inductively coupled plasma-sector field mass spectrometry. Fresenius J Anal Chem (2001) 371:764-774, doi:10.1007/s002160101019
Griesel, S., Reus, U., & Prange, A. (2001): Electro-deposition as a sample preparation technique for total-reflection X-ray fluorescence analysis. Spectrochim. Acta B 56 (2001) 2107-2115, doi:10.1016/S0584-8547(01)00319-6
Frank, B., Reincke, H., & Prange, A. (2000): Informationssysteme ELISE und ELBIS - Instrumente für Forschung und Praxis: Teil 1 - Das Elbe-Informationssystem ELBIS. In: Gewässerlandschaften (...) ATV-DVWK-Schriftenreihe 21 (2000) ISBN 3-933707-65-X
Prange, A., et al. (2000): Die Elbe und ihre Nebenflüsse: Belastung, Trends, Bewertung, Perspektiven. In ATV-DVWK Deutsche Vereinigung für Wasserwirtschaft, Abwasser und Abfall e.V. Hennef: GfA Gesellschaft zur Förderung der Abwassertechnik e.V. [ed.]: (2000), ISBN 3-933707-63-3